학술논문
Poliovirus-Neutralizing Antibody Seroprevalence and Vaccine Habits in a Vaccine-Derived Poliovirus Outbreak Region in the Democratic Republic of Congo in 2018: The Impact on the Global Eradication Initiative.
Document Type
article
Author
Musene, Kamy; Dzogang, Camille; Sinai, Cyrus; Spencer, DAndre; Ngoie-Mwamba, Guillaume; Tangney, Sylvia; Salet, Frank; Nyembwe, Michel; Kambamba Nzaji, Michel; Tambu, Merly; Mbala, Placide; Gerber, Sue; Kaba, Didine; Muyembe-Tamfum, Jean; Rimoin, Anne; Gadoth, Adva; Mukadi, Patrick; Fuller, Trevon; Hoff, Nicole; Halbrook, Megan
Source
Vaccines. 12(3)
Subject
Language
Abstract
Despite the successes in wild-type polio eradication, poor vaccine coverage in the DRC has led to the occurrence of circulating vaccine-derived poliovirus outbreaks. This cross-sectional population-based survey provides an update to previous poliovirus-neutralizing antibody seroprevalence studies in the DRC and quantifies risk factors for under-immunization and parental knowledge that guide vaccine decision making. Among the 964 children between 6 and 35 months in our survey, 43.8% (95% CI: 40.6-47.0%), 41.1% (38.0-44.2%), and 38.0% (34.9-41.0%) had protective neutralizing titers to polio types 1, 2, and 3, respectively. We found that 60.7% of parents reported knowing about polio, yet 25.6% reported knowing how it spreads. Our data supported the conclusion that polio outreach efforts were successfully connecting with communities-79.4% of participants had someone come to their home with information about polio, and 88.5% had heard of a polio vaccination campaign. Additionally, the odds of seroreactivity to only serotype 2 were far greater in health zones that had a history of supplementary immunization activities (SIAs) compared to health zones that did not. While SIAs may be reaching under-vaccinated communities as a whole, these results are a continuation of the downward trend of seroprevalence rates in this region.