학술논문
Multi-ancestry genome-wide gene–sleep interactions identify novel loci for blood pressure
Document Type
article
Author
Wang, Heming; Noordam, Raymond; Cade, Brian E; Schwander, Karen; Winkler, Thomas W; Lee, Jiwon; Sung, Yun Ju; Bentley, Amy R; Manning, Alisa K; Aschard, Hugues; Kilpeläinen, Tuomas O; Ilkov, Marjan; Brown, Michael R; Horimoto, Andrea R; Richard, Melissa; Bartz, Traci M; Vojinovic, Dina; Lim, Elise; Nierenberg, Jovia L; Liu, Yongmei; Chitrala, Kumaraswamynaidu; Rankinen, Tuomo; Musani, Solomon K; Franceschini, Nora; Rauramaa, Rainer; Alver, Maris; Zee, Phyllis C; Harris, Sarah E; van der Most, Peter J; Nolte, Ilja M; Munroe, Patricia B; Palmer, Nicholette D; Kühnel, Brigitte; Weiss, Stefan; Wen, Wanqing; Hall, Kelly A; Lyytikäinen, Leo-Pekka; O’Connell, Jeff; Eiriksdottir, Gudny; Launer, Lenore J; de Vries, Paul S; Arking, Dan E; Chen, Han; Boerwinkle, Eric; Krieger, Jose E; Schreiner, Pamela J; Sidney, Stephen; Shikany, James M; Rice, Kenneth; Chen, Yii-Der Ida; Gharib, Sina A; Bis, Joshua C; Luik, Annemarie I; Ikram, M Arfan; Uitterlinden, André G; Amin, Najaf; Xu, Hanfei; Levy, Daniel; He, Jiang; Lohman, Kurt K; Zonderman, Alan B; Rice, Treva K; Sims, Mario; Wilson, Gregory; Sofer, Tamar; Rich, Stephen S; Palmas, Walter; Yao, Jie; Guo, Xiuqing; Rotter, Jerome I; Biermasz, Nienke R; Mook-Kanamori, Dennis O; Martin, Lisa W; Barac, Ana; Wallace, Robert B; Gottlieb, Daniel J; Komulainen, Pirjo; Heikkinen, Sami; Mägi, Reedik; Milani, Lili; Metspalu, Andres; Starr, John M; Milaneschi, Yuri; Waken, RJ; Gao, Chuan; Waldenberger, Melanie; Peters, Annette; Strauch, Konstantin; Meitinger, Thomas; Roenneberg, Till; Völker, Uwe; Dörr, Marcus; Shu, Xiao-Ou; Mukherjee, Sutapa; Hillman, David R; Kähönen, Mika; Wagenknecht, Lynne E; Gieger, Christian; Grabe, Hans J; Zheng, Wei
Source
Molecular Psychiatry. 26(11)
Subject
Language
Abstract
Long and short sleep duration are associated with elevated blood pressure (BP), possibly through effects on molecular pathways that influence neuroendocrine and vascular systems. To gain new insights into the genetic basis of sleep-related BP variation, we performed genome-wide gene by short or long sleep duration interaction analyses on four BP traits (systolic BP, diastolic BP, mean arterial pressure, and pulse pressure) across five ancestry groups in two stages using 2 degree of freedom (df) joint test followed by 1df test of interaction effects. Primary multi-ancestry analysis in 62,969 individuals in stage 1 identified three novel gene by sleep interactions that were replicated in an additional 59,296 individuals in stage 2 (stage 1 + 2 Pjoint