학술논문
Ventilation practices in burn patients—an international prospective observational cohort study
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article
Author
Schultz, Marcus J; Horn, Janneke; Hollmann, Markus W; Preckel, Benedikt; Glas, Gerie J; Colpaert, Kirsten; Malbrain, Manu; Neto, Ary Serpa; Asehnoune, Karim; de Abreu, Marcello Gamma; Martin-Loeches, Ignacio; Pelosi, Paolo; Sjöberg, Folke; Binnekade, Jan M; Cleffken, Berry; Juffermans, Nicole P; Knape, Paul; Loef, Bert G; Mackie, David P; Enkhbaatar, Perenlei; Depetris, Nadia; Perner, Anders; Herrero, Eva; Cachafeiro, Lucia; Jeschke, Marc; Lipman, Jeffrey; Legrand, Matthieu; Horter, Johannes; Lavrentieva, Athina; Glas, Gerie; Kazemi, Alex; Guttormsen, Anne Berit; Huss, Frederik; Kol, Mark; Wong, Helen; Starr, Therese; De Crop, Luc; de Oliveira Filho, Wilson; Silva, João Manoel; Grion, Cintia MC; Jeschke, Marc G; Burnett, Marjorie; Mondrup, Frederik; Ravat, Francois; Fontaine, Mathieu; Asehoune, Karim; Le Floch, Renan; Jeanne, Mathieu; Bacus, Morgane; Chaussard, Maïté; Lehnhardt, Marcus; Mikhail, Bassem Daniel; Gille, Jochen; Sharkey, Aidan; Trommel, Nicole; Reidinga, Auke C; Vieleers, Nadine; Tilsley, Anna; Onarheim, Henning; Bouza, Maria Teresa; Agrifoglio, Alexander; Fredén, Filip; Palmieri, Tina; Painting, Lynda E; investigators, LAMiNAR
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Abstract
BackgroundIt is unknown whether lung-protective ventilation is applied in burn patients and whether they benefit from it. This study aimed to determine ventilation practices in burn intensive care units (ICUs) and investigate the association between lung-protective ventilation and the number of ventilator-free days and alive at day 28 (VFD-28).MethodsThis is an international prospective observational cohort study including adult burn patients requiring mechanical ventilation. Low tidal volume (V T) was defined as V T ≤ 8 mL/kg predicted body weight (PBW). Levels of positive end-expiratory pressure (PEEP) and maximum airway pressures were collected. The association between V T and VFD-28 was analyzed using a competing risk model. Ventilation settings were presented for all patients, focusing on the first day of ventilation. We also compared ventilation settings between patients with and without inhalation trauma.ResultsA total of 160 patients from 28 ICUs in 16 countries were included. Low V T was used in 74% of patients, median V T size was 7.3 [interquartile range (IQR) 6.2-8.3] mL/kg PBW and did not differ between patients with and without inhalation trauma (p = 0.58). Median VFD-28 was 17 (IQR 0-26), without a difference between ventilation with low or high V T (p = 0.98). All patients were ventilated with PEEP levels ≥5 cmH2O; 80% of patients had maximum airway pressures