학술논문
Association of immunosuppression and HIV viraemia with non-Hodgkin lymphoma risk overall and by subtype in people living with HIV in Canada and the USA: a multicentre cohort study
Document Type
article
Author
Hernández-Ramírez, Raúl U; Qin, Li; Lin, Haiqun; Leyden, Wendy; Neugebauer, Romain S; Althoff, Keri N; Achenbach, Chad J; Hessol, Nancy A; D'Souza, Gypsyamber; Gebo, Kelly A; Gill, M John; Grover, Surbhi; Horberg, Michael A; Li, Jun; Mathews, W Christopher; Mayor, Angel M; Park, Lesley S; Rabkin, Charles S; Salters, Kate; Justice, Amy C; Moore, Richard D; Engels, Eric A; Silverberg, Michael J; Dubrow, Robert; AIDS, North American AIDS Cohort Collaboration on Research and Design of the International Epidemiologic Databases to Evaluate; Betts, Adrian; Brooks, John T; Freeman, Aimee M; Van Rompaey, Stephen E; Burchell, Ann; Yip, Benita; You, Bin; Hogan, Brenna; Grasso, Chris; Hogg, Robert S; Benson, Constance A; Drozd, Daniel R; Sterling, Timothy R; Haas, David; Humes, Elizabeth; Crane, Heidi M; Willig, James; Eron, Joseph J; Martin, Jeffrey N; Saag, Michael S; Jing, Jerry; Zhang, Jinbing; Lindsay, Joanne; Hunter-Mellado, Robert F; Deeks, Steven G; Zhu, Julia; Montaner, Julio SG; McReynolds, Justin; Gabler, Karyn; Buchacz, Kate; Rodriguez, Benigno; Thorne, Jennifer E; Margolick, Joseph B; Anastos, Kathryn; Jacobson, Lisa P; Klein, Marina B; Kroch, Abigail; Morton, Liz; Turner, Megan; Fiellin, David; Gange, Stephen J; Mugavero, Michael J; Harrigan, P Richard; Rebeiro, Peter; Bosch, Ronald J; Kirk, Gregory D; Mayer, Kenneth H; McKaig, Rosemary G; Coburn, Sally; Napravnik, Sonia; Kitahata, Mari M; Lober, William B; Lee, Jennifer S
Source
The Lancet HIV. 6(4)
Subject
Language
Abstract
BackgroundResearch is needed to better understand relations between immunosuppression and HIV viraemia and risk for non-Hodgkin lymphoma, a common cancer in people living with HIV. We aimed to identify key CD4 count and HIV RNA (viral load) predictors of risk for non-Hodgkin lymphoma, overall and by subtype.MethodsWe studied people living with HIV during 1996-2014 from 21 Canadian and US cohorts participating in the North American AIDS Cohort Collaboration on Research and Design. To determine key independent predictors of risk for non-Hodgkin lymphoma, we assessed associations with time-updated recent, past, cumulative, and nadir or peak measures of CD4 count and viral load, using demographics-adjusted, cohort-stratified Cox models, and we compared models using Akaike's information criterion.FindingsOf 102 131 people living with HIV during the study period, 712 people developed non-Hodgkin lymphoma. The key independent predictors of risk for overall non-Hodgkin lymphoma were recent CD4 count (ie, lagged by 6 months;