학술논문

Allogeneic Stem Cell Transplantation for Advanced Myelodysplastic Syndrome: Comparison of Outcomes between CD34+ Selected and Unmodified Hematopoietic Stem Cell Transplantation
Document Type
article
Source
Transplantation and Cellular Therapy. 24(5)
Subject
Biomedical and Clinical Sciences
Cardiovascular Medicine and Haematology
Rare Diseases
Clinical Research
Transplantation
Stem Cell Research - Nonembryonic - Human
Orphan Drug
Stem Cell Research
Regenerative Medicine
Adult
Aged
Allografts
Antigens
CD34
Chromosome Aberrations
Female
Graft vs Host Disease
Hematopoietic Stem Cell Transplantation
Humans
Lymphocyte Depletion
Male
Middle Aged
Myelodysplastic Syndromes
Recurrence
Risk Assessment
Survival Analysis
Transplantation
Homologous
Treatment Outcome
Myelodysplastic syndrome
Allogeneic transplantation
T cell depletion
Unmodified
Clinical Sciences
Immunology
Cardiovascular medicine and haematology
Language
Abstract
In this study, we compared transplantation outcomes of allogeneic hematopoietic stem cell transplantation (HSCT) in patients with advanced myelodysplastic syndrome (MDS) who received a CD34+ cell-selected and those who received an unmodified allograft. This analysis initially included 181 patients, 60 who received a CD34+ cell-selected transplant and 121 who received an unmodified transplant. Owing to significant differences in disease characteristics, the analysis was limited to patients with