학술논문
Cryptic transmission of SARS-CoV-2 in Washington state
Document Type
article
Author
Bedford, Trevor; Greninger, Alexander L; Roychoudhury, Pavitra; Starita, Lea M; Famulare, Michael; Huang, Meei-Li; Nalla, Arun; Pepper, Gregory; Reinhardt, Adam; Xie, Hong; Shrestha, Lasata; Nguyen, Truong N; Adler, Amanda; Brandstetter, Elisabeth; Cho, Shari; Giroux, Danielle; Han, Peter D; Fay, Kairsten; Frazar, Chris D; Ilcisin, Misja; Lacombe, Kirsten; Lee, Jover; Kiavand, Anahita; Richardson, Matthew; Sibley, Thomas R; Truong, Melissa; Wolf, Caitlin R; Nickerson, Deborah A; Rieder, Mark J; Englund, Janet A; Hadfield, James; Hodcroft, Emma B; Huddleston, John; Moncla, Louise H; Müller, Nicola F; Neher, Richard A; Deng, Xianding; Gu, Wei; Federman, Scot; Chiu, Charles; Duchin, Jeffrey S; Gautom, Romesh; Melly, Geoff; Hiatt, Brian; Dykema, Philip; Lindquist, Scott; Queen, Krista; Tao, Ying; Uehara, Anna; Tong, Suxiang; MacCannell, Duncan; Armstrong, Gregory L; Baird, Geoffrey S; Chu, Helen Y; Shendure, Jay; Jerome, Keith R; Boeckh, Michael; Lutz, Barry R; Thompson, Matthew; Huang, Shichu; Jackson, Michael L; Kimball, Louise E; Logue, Jennifer; Lyon, Victoria; Newman, Kira L; Suchsland, Monica L Zigman
Source
Science. 370(6516)
Subject
Language
Abstract
After its emergence in Wuhan, China, in late November or early December 2019, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus rapidly spread globally. Genome sequencing of SARS-CoV-2 allows the reconstruction of its transmission history, although this is contingent on sampling. We analyzed 453 SARS-CoV-2 genomes collected between 20 February and 15 March 2020 from infected patients in Washington state in the United States. We find that most SARS-CoV-2 infections sampled during this time derive from a single introduction in late January or early February 2020, which subsequently spread locally before active community surveillance was implemented.