학술논문
Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): An update on 107 randomized trials and 19,805 patients, on behalf of MACH-NC Group
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article
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Lacas, Benjamin; Carmel, Alexandra; Landais, Cécile; Wong, Stuart J; Licitra, Lisa; Tobias, Jeffrey S; Burtness, Barbara; Ghi, Maria Grazia; Cohen, Ezra EW; Grau, Cai; Wolf, Gregory; Hitt, Ricardo; Corvò, Renzo; Budach, Volker; Kumar, Shaleen; Laskar, Sarbani Ghosh; Mazeron, Jean-Jacques; Zhong, Lai-Ping; Dobrowsky, Werner; Ghadjar, Pirus; Fallai, Carlo; Zakotnik, Branko; Sharma, Atul; Bensadoun, René-Jean; Redda, Maria Grazia Ruo; Racadot, Séverine; Fountzilas, George; Brizel, David; Rovea, Paolo; Argiris, Athanassios; Nagy, Zoltán Takácsi; Lee, Ju-Whei; Fortpied, Catherine; Harris, Jonathan; Bourhis, Jean; Aupérin, Anne; Blanchard, Pierre; Pignon, Jean-Pierre; Group, MACH-NC Collaborative; Adelstein, DJ; Alfonsi, M; Belkacemi, Y; Bar-Ad, V; Bernier, J; Bratland, Å; Calais, G; Campbell, B; Caudell, J; Chabaud, S; Chamorey, E; Chaukar, D; Choi, KN; Choussy, O; Collette, L; Cruz, JJ; Dani, C; Dauzier, E; Forastiere, AA; Garaud, P; Gregoire, V; Hackshaw, A; Haddad, E; Haffty, BG; Hansen, A; Hayoz, S; Horiot, JC; Jeremic, B; Karrison, TG; Langendijk, JA; Lapeyre, M; Lartigau, E; Leong, T; Le, QT; Lee, PPY; Lewin, F; Lin, A; Lopes, A; Mehta, S; Moon, J; Moyal, E; Occéan, BV; Olmi, P; Orecchia, R; O'Sullivan, B; Overgaard, J; Petit, C; Quon, H; Sanguineti, G; Satar, T; Simes, J; Simon, C; Sire, C; Staar, S; Stromberger, C; Strojan, P; Temam, S; Thomson, D; Timochenko, A; Torri, V; Tseroni, V
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Abstract
Background and purposeThe Meta-Analysis of Chemotherapy in squamous cell Head and Neck Cancer (MACH-NC) demonstrated that concomitant chemotherapy (CT) improved overall survival (OS) in patients without distant metastasis. We report the updated results.Materials and methodsPublished or unpublished randomized trials including patients with non-metastatic carcinoma randomized between 1965 and 2016 and comparing curative loco-regional treatment (LRT) to LRT + CT or adding another timing of CT to LRT + CT (main question), or comparing induction CT + radiotherapy to radiotherapy + concomitant (or alternating) CT (secondary question) were eligible. Individual patient data were collected and combined using a fixed-effect model. OS was the main endpoint.ResultsFor the main question, 101 trials (18951 patients, median follow-up of 6.5 years) were analyzed. For both questions, there were 16 new (2767 patients) and 11 updated trials. Around 90% of the patients had stage III or IV disease. Interaction between treatment effect on OS and the timing of CT was significant (p