학술논문
Telomere length associates with chronological age and mortality across racially diverse pulmonary fibrosis cohorts
Document Type
article
Author
Adegunsoye, Ayodeji; Newton, Chad A; Oldham, Justin M; Ley, Brett; Lee, Cathryn T; Linderholm, Angela L; Chung, Jonathan H; Garcia, Nicole; Zhang, Da; Vij, Rekha; Guzy, Robert; Jablonski, Renea; Bag, Remzi; Voogt, Rebecca S; Ma, Shwu-Fan; Sperling, Anne I; Raghu, Ganesh; Martinez, Fernando J; Strek, Mary E; Wolters, Paul J; Garcia, Christine Kim; Pierce, Brandon L; Noth, Imre
Source
Nature Communications. 14(1)
Subject
Language
Abstract
Pulmonary fibrosis (PF) is characterized by profound scarring and poor survival. We investigated the association of leukocyte telomere length (LTL) with chronological age and mortality across racially diverse PF cohorts. LTL measurements among participants with PF stratified by race/ethnicity were assessed in relation to age and all-cause mortality, and compared to controls. Generalized linear models were used to evaluate the age-LTL relationship, Cox proportional hazards models were used for hazard ratio estimation, and the Cochran-Armitage test was used to assess quartiles of LTL. Standardized LTL shortened with increasing chronological age; this association in controls was strengthened in PF (R = -0.28; P