학술논문
SARS-CoV-2 Infection Dysregulates the Metabolomic and Lipidomic Profiles of Serum.
Document Type
article
Author
Bruzzone, Chiara; Bizkarguenaga, Maider; Gil-Redondo, Rubén; Diercks, Tammo; Arana, Eunate; García de Vicuña, Aitor; Seco, Marisa; Bosch, Alexandre; Palazón, Asís; San Juan, Itxaso; Laín, Ana; Gil-Martínez, Jon; Bernardo-Seisdedos, Ganeko; Fernández-Ramos, David; Lopitz-Otsoa, Fernando; Embade, Nieves; Lu, Shelly; Mato, José M; Millet, Oscar
Source
iScience. 23(10)
Subject
Language
Abstract
COVID-19 is a systemic infection that exerts significant impact on the metabolism. Yet, there is little information on how SARS-CoV-2 affects metabolism. Using NMR spectroscopy, we measured the metabolomic and lipidomic serum profile from 263 (training cohort) + 135 (validation cohort) symptomatic patients hospitalized after positive PCR testing for SARS-CoV-2 infection. We also established the profiles of 280 persons collected before the coronavirus pandemic started. Principal-component analysis discriminated both cohorts, highlighting the impact that the infection has on overall metabolism. The lipidomic analysis unraveled a pathogenic redistribution of the lipoprotein particle size and composition to increase the atherosclerotic risk. In turn, metabolomic analysis reveals abnormally high levels of ketone bodies (acetoacetic acid, 3-hydroxybutyric acid, and acetone) and 2-hydroxybutyric acid, a readout of hepatic glutathione synthesis and marker of oxidative stress. Our results are consistent with a model in which SARS-CoV-2 infection induces liver damage associated with dyslipidemia and oxidative stress.