학술논문
Outcome measures for Alzheimer's disease: A global inter‐societal Delphi consensus
Document Type
article
Author
Ellison, Tim S; Cappa, Stefano F; Garrett, Dawne; Georges, Jean; Iwatsubo, Takeshi; Kramer, Joel H; Lehmann, Maryna; Lyketsos, Constantine; Maier, Andrea B; Merrilees, Jennifer; Morris, John C; Naismith, Sharon L; Nobili, Flavio; Pahor, Marco; Pond, Dimity; Robinson, Louise; Soysal, Pinar; Vandenbulcke, Mathieu; Weber, Christopher J; Visser, Pieter Jelle; Weiner, Michael; Frisoni, Giovanni B
Source
Alzheimer's & Dementia. 19(6)
Subject
Language
Abstract
IntroductionWe aim to provide guidance on outcomes and measures for use in patients with Alzheimer's clinical syndrome.MethodsA consensus group of 20 voting members nominated by 10 professional societies, and a non-voting chair, used a Delphi approach and modified GRADE criteria.ResultsConsensus was reached on priority outcomes (n = 66), measures (n = 49) and statements (n = 37) across nine domains. A number of outcomes and measurement instruments were ranked for: Cognitive abilities; Functional abilities/dependency; Behavioural and neuropsychiatric symptoms; Patient quality of life (QoL); Caregiver QoL; Healthcare and treatment-related outcomes; Medical investigations; Disease-related life events; and Global outcomes.DiscussionThis work provides indications on the domains and ideal pertinent measurement instruments that clinicians may wish to use to follow patients with cognitive impairment. More work is needed to develop instruments that are more feasible in the context of the constraints of clinical routine.