학술논문

Damage Control as a Strategy to Manage Postreperfusion Hemodynamic Instability and Coagulopathy in Liver Transplant.
Document Type
article
Source
JAMA surgery. 150(11)
Subject
Humans
Liver Failure
Reperfusion Injury
Postoperative Complications
Treatment Outcome
Liver Transplantation
Reoperation
Survival Rate
Multivariate Analysis
Confidence Intervals
Logistic Models
Markov Chains
Odds Ratio
Retrospective Studies
Cohort Studies
Follow-Up Studies
Graft Rejection
Graft Survival
Time Factors
Reference Values
Databases
Factual
Female
Male
Hemodynamics
Kaplan-Meier Estimate
Liver Disease
Transplantation
Clinical Research
Digestive Diseases
Organ Transplantation
Rare Diseases
6.4 Surgery
Evaluation of treatments and therapeutic interventions
Oral and gastrointestinal
Language
Abstract
ImportanceDamage control (DC) with intra-abdominal packing and delayed reconstruction is an accepted strategy in trauma and acute care surgery but has not been evaluated in liver transplant.ObjectiveTo evaluate the incidence, effect on survival, and predictors of the need for DC using intra-abdominal packing and delayed biliary reconstruction in patients with coagulopathy or hemodynamic instability after liver allograft reperfusion.Design, setting, and participantsWe performed a retrospective analysis of adults undergoing liver transplant at a large transplant center from February 1, 2002, through July 31, 2012.Main outcomes and measuresPredictors of DC, effects on graft, and patient survival.ResultsOf 1813 patients, 150 (8.3%) underwent DC during liver transplant, with 84 (56.0%) requiring a single additional operation for biliary reconstruction and abdominal closure and 57 (38.0%) requiring multiple additional operations. Compared with recipients without DC, patients requiring DC had greater Model for End-stage Liver Disease scores (33 vs 27; P