학술논문
Subclinical Thyroid Dysfunction and Fracture Risk: A Meta-analysis
Document Type
article
Author
Blum, Manuel R; Bauer, Douglas C; Collet, Tinh-Hai; Fink, Howard A; Cappola, Anne R; da Costa, Bruno R; Wirth, Christina D; Peeters, Robin P; Åsvold, Bjørn O; Elzen, Wendy PJ den; Luben, Robert N; Imaizumi, Misa; Bremner, Alexandra P; Gogakos, Apostolos; Eastell, Richard; Kearney, Patricia M; Strotmeyer, Elsa S; Wallace, Erin R; Hoff, Mari; Ceresini, Graziano; Rivadeneira, Fernando; Uitterlinden, André G; Stott, David J; Westendorp, Rudi GJ; Khaw, Kay-Tee; Langhammer, Arnuf; Ferrucci, Luigi; Gussekloo, Jacobijn; Williams, Graham R; Walsh, John P; Jüni, Peter; Aujesky, Drahomir; Rodondi, Nicolas
Source
JAMA. 313(20)
Subject
Language
Abstract
ImportanceAssociations between subclinical thyroid dysfunction and fractures are unclear and clinical trials are lacking.ObjectiveTo assess the association of subclinical thyroid dysfunction with hip, nonspine, spine, or any fractures.Data sources and study selectionThe databases of MEDLINE and EMBASE (inception to March 26, 2015) were searched without language restrictions for prospective cohort studies with thyroid function data and subsequent fractures.Data extractionIndividual participant data were obtained from 13 prospective cohorts in the United States, Europe, Australia, and Japan. Levels of thyroid function were defined as euthyroidism (thyroid-stimulating hormone [TSH], 0.45-4.49 mIU/L), subclinical hyperthyroidism (TSH