학술논문
Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant.
Document Type
article
Author
Earnshaw, WC; Allshire, RC; Black, BE; Bloom, K; Brinkley, BR; Brown, W; Cheeseman, IM; Choo, KHA; Copenhaver, GP; Deluca, JG; Desai, A; Diekmann, S; Erhardt, S; Fitzgerald-Hayes, M; Foltz, D; Fukagawa, T; Gassmann, R; Gerlich, DW; Glover, DM; Gorbsky, GJ; Harrison, SC; Heun, P; Hirota, T; Jansen, LET; Karpen, G; Kops, GJPL; Lampson, MA; Lens, SM; Losada, A; Luger, K; Maiato, H; Maddox, PS; Margolis, RL; Masumoto, H; McAinsh, AD; Mellone, BG; Meraldi, P; Musacchio, A; Oegema, K; O'Neill, RJ; Salmon, ED; Scott, KC; Straight, AF; Stukenberg, PT; Sullivan, BA; Sullivan, KF; Sunkel, CE; Swedlow, JR; Walczak, CE; Warburton, PE; Westermann, S; Willard, HF; Wordeman, L; Yanagida, M; Yen, TJ; Yoda, K; Cleveland, DW
Source
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology. 21(2)
Subject
Language
Abstract
The first centromeric protein identified in any species was CENP-A, a divergent member of the histone H3 family that was recognised by autoantibodies from patients with scleroderma-spectrum disease. It has recently been suggested to rename this protein CenH3. Here, we argue that the original name should be maintained both because it is the basis of a long established nomenclature for centromere proteins and because it avoids confusion due to the presence of canonical histone H3 at centromeres.