학술논문

Predictability and stability testing to assess clinical decision instrument performance for children after blunt torso trauma
Document Type
article
Source
PLOS Digital Health. 1(8)
Subject
Biomedical and Clinical Sciences
Clinical Sciences
Biodefense
Pediatric
Vaccine Related
Prevention
Clinical Research
Language
Abstract
ObjectiveThe Pediatric Emergency Care Applied Research Network (PECARN) has developed a clinical-decision instrument (CDI) to identify children at very low risk of intra-abdominal injury. However, the CDI has not been externally validated. We sought to vet the PECARN CDI with the Predictability Computability Stability (PCS) data science framework, potentially increasing its chance of a successful external validation.Materials & methodsWe performed a secondary analysis of two prospectively collected datasets: PECARN (12,044 children from 20 emergency departments) and an independent external validation dataset from the Pediatric Surgical Research Collaborative (PedSRC; 2,188 children from 14 emergency departments). We used PCS to reanalyze the original PECARN CDI along with new interpretable PCS CDIs developed using the PECARN dataset. External validation was then measured on the PedSRC dataset.ResultsThree predictor variables (abdominal wall trauma, Glasgow Coma Scale Score