학술논문
Alignment of parent- and child-reported outcomes and histology in eosinophilic esophagitis across multiple CEGIR sites
Document Type
article
Author
Aceves, Seema S; King, Eileen; Collins, Margaret H; Yang, Guang-Yu; Capocelli, Kelley E; Abonia, J Pablo; Atkins, Dan; Bonis, Peter A; Carpenter, Christina L; Dellon, Evan S; Eby, Michael D; Falk, Gary W; Gonsalves, Nirmala; Gupta, Sandeep K; Hirano, Ikuo; Kocher, Kendra; Krischer, Jeffrey P; Leung, John; Lipscomb, Jessi; Menard-Katcher, Paul; Mukkada, Vincent A; Pan, Zhaoxing; Spergel, Jonathan M; Sun, Qin; Wershil, Barry K; Rothenberg, Marc E; Furuta, Glenn T; Researchers, Consortium of Eosinophilic Gastrointestinal Disease; Arrington, Ashley; Bailey, Jeanie; Besse, John; Book, Wendy M; Burke, Deirdre; Covington, Jacquelyn; DeMarschall, Maureen; Dohil, Ranjan; Dubner, Allison; Foote, Heather; Guan, Shaobo; Hurnton, Alicia; Kodroff, Ellyn; Kuhl, Jonathan; Kyle, Shay; Lewis, Megan; Mack, Denise; McGee, Sarah; Mingler, Melissa; Moist, Susan; Muir, Amanda; Poppendeck, Heidi; Putnam, Philip; Reidy, Cathy; Rudman-Spergel, Amanda K; Sable, Kathleen; Scott, Melissa; Strobel, Mary Jo; Thompson, Katherine; Wechsler, Joshua
Source
Journal of Allergy and Clinical Immunology. 142(1)
Subject
Language
Abstract
BACKGROUND:Patient-reported outcome metrics for eosinophilic esophagitis (EoE) have been developed and validated but not used in a multicenter pediatric population or systematically aligned with histology. OBJECTIVE:We sought to understand (1) the potential of caregiver report to predict patient self-reported symptoms and (2) the correlation of patient-reported outcome domains with histology. METHODS:Patients with EoE (n = 310) and their parents participating in the Consortium of Gastrointestinal Eosinophilic Disease Researchers (CEGIR) observational clinical trial were queried for baseline patient symptoms and quality of life (QOL) by using the Pediatric Eosinophilic Esophagitis Symptom Score, version 2 (PEESSv2.0), and the Pediatric QOL EoE module (PedsQL-EoE), and biopsy specimens were analyzed by using the EoE Histology Scoring System. RESULTS:PEESSv2.0 parental and child reports aligned across all domains (r = 0.68-0.73, P