학술논문

Plasma mineral status after a six-month intervention providing one egg per day to young Malawian children: a randomized controlled trial
Document Type
article
Source
Scientific Reports. 13(1)
Subject
Biomedical and Clinical Sciences
Nutrition and Dietetics
Pediatric
Clinical Research
Clinical Trials and Supportive Activities
Nutrition
Prevention
7.1 Individual care needs
Prevention of disease and conditions
and promotion of well-being
3.3 Nutrition and chemoprevention
Management of diseases and conditions
Cardiovascular
Humans
Child
Child
Preschool
Copper
Selenium
Malnutrition
Iron
Zinc
Language
Abstract
Mineral deficiencies are common in children living in low-resource areas. Eggs are a rich source of essential nutrients and have been shown to improve growth in young children, although little is known about their impact on mineral status. Children aged 6-9 months (n = 660) were randomized to receive either one egg/day for 6-months or no intervention. Anthropometric data, dietary recalls, and venous blood were collected at baseline and 6-months follow-up. Quantification of plasma minerals (n = 387) was done using inductively coupled plasma-mass spectroscopy. Difference-in-difference mean plasma mineral concentrations was determined from baseline and follow-up values and assessed between groups by intention-to-treat using ANCOVA regression models. Prevalence of zinc deficiency was 57.4% at baseline and 60.5% at follow-up. Mean difference (MD) of plasma magnesium, selenium, copper, and zinc levels were not different between groups. Plasma iron concentrations were significantly lower in the intervention compared to the control group (MD = - 9.29; 95% CI: - 15.95, - 2.64). Zinc deficiency was widely prevalent in this population. Mineral deficiencies were not addressed with the egg intervention. Further interventions are needed to improve the mineral status of young children.