학술논문
Low liver fat in non‐alcoholic steatohepatitis‐related significant fibrosis and cirrhosis is associated with hepatocellular carcinoma, decompensation and mortality
Document Type
article
Author
Lee, Sung Won; Huang, Daniel Q; Bettencourt, Ricki; Ajmera, Veeral; Tincopa, Monica; Noureddin, Nabil; Amangurbanova, Maral; Siddiqi, Harris; Madamba, Egbert; Majzoub, Abdul M; Nayfeh, Tarek; Tamaki, Nobuharu; Izumi, Namiki; Nakajima, Atsushi; Yoneda, Masato; Idilman, Ramzan; Gumussoy, Mesut; Oz, Digdem Kuru; Erden, Ayse; Loomba, Rohit
Source
Alimentary Pharmacology & Therapeutics. 59(1)
Subject
Language
Abstract
BackgroundProgression to cirrhosis in non-alcoholic steatohepatitis (NASH) is associated with a decrease in liver fat. However, the prognostic significance of liver fat content in NASH-related significant fibrosis and cirrhosis is unclear.AimTo investigate the risk of decompensation, hepatocellular carcinoma (HCC) and mortality stratified by liver fat content in NASH-related significant fibrosis and cirrhosis.MethodsIn this meta-analysis of individual participant data, 456 patients with both magnetic resonance elastography (MRE) and MRI-derived protein density fat fraction (MRI-PDFF) were enrolled, and 296 patients with longitudinal follow-up were analysed. MRE combined with fibrosis-4 (MEFIB-index), and MRI-PDFF were used to measure liver fibrosis and fat, respectively. MEFIB-negative, MEFIB-positive+ MRI-PDFF ≥5% and MEFIB-positive+ MRI-PDFF