학술논문
Household air pollution and risk of pulmonary tuberculosis in HIV-Infected adults.
Document Type
article
Author
Katoto, Patrick; Bihehe, Dieudonné; Brand, Amanda; Mushi, Raymond; Kusinza, Aline; Alwood, Brian; van Zyl-Smit, Richard; Tamuzi, Jacques; Sam-Agudu, Nadia; Yotebieng, Marcel; Metcalfe, John; Theron, Grant; Godri Pollitt, Krystal; Lesosky, Maia; Vanoirbeek, Jeroen; Mortimer, Kevin; Nawrot, Tim; Nemery, Benoit; Nachega, Jean
Source
Environmental Health: A Global Access Science Source. 23(1)
Subject
Language
Abstract
BACKGROUND: In low- and middle-income countries countries, millions of deaths occur annually from household air pollution (HAP), pulmonary tuberculosis (PTB), and HIV-infection. However, it is unknown whether HAP influences PTB risk among people living with HIV-infection. METHODS: We conducted a case-control study among 1,277 HIV-infected adults in Bukavu, eastern Democratic Republic of Congo (February 2018 - March 2019). Cases had current or recent (3h/day and ≥2 times/day and ≥5 days/week were more likely to have PTB (aOR 1·36; 95%CI 1·06-1·75) than those spending less time in the kitchen. Time-weighted average 24h personal CO exposure was related dose-dependently with the likelihood of having PTB, with aOR 4·64 (95%CI 1·1-20·7) for the highest quintile [12·3-76·2 ppm] compared to the lowest quintile [0·1-1·9 ppm]. CONCLUSION: Time spent cooking and personal CO exposure were independently associated with increased risk of PTB among people living with HIV. Considering the high burden of TB-HIV coinfection in the region, effective interventions are required to decrease HAP exposure caused by cooking with biomass among people living with HIV, especially women.