학술논문

Hematologic, Hepatic, Renal, and Lipid Laboratory Monitoring After Initiation of Combination Antiretroviral Therapy in the United States, 2000–2010
Document Type
article
Source
JAIDS Journal of Acquired Immune Deficiency Syndromes. 63(2)
Subject
Biomedical and Clinical Sciences
Clinical Sciences
Kidney Disease
Clinical Research
Digestive Diseases
Liver Disease
Evaluation of treatments and therapeutic interventions
6.1 Pharmaceuticals
Alanine Transaminase
Anti-HIV Agents
Antiretroviral Therapy
Highly Active
Aspartate Aminotransferases
Bilirubin
Blood Cell Count
Cohort Studies
Creatinine
Drug Monitoring
Female
HIV Infections
Hematologic Tests
Humans
Kidney
Lipids
Liver
Male
United States
laboratory monitoring
antiretroviral therapy
antiretroviral toxicity
Center for Aids Research Network of Integrated Clinical Systems (CNICS) Cohort Study
Public Health and Health Services
Virology
Clinical sciences
Epidemiology
Public health
Language
Abstract
We assessed laboratory monitoring after combination antiretroviral therapy initiation among 3678 patients in a large US multisite clinical cohort, censoring participants at last clinic visit, combination antiretroviral therapy change, or 3 years. Median days (interquartile range) to first hematologic, hepatic, renal, and lipid tests were 30 (18-53), 31 (19-56), 33 (20-59), and 350 (96-1106), respectively. At 1 year, approximately 80% received more than 2 hematologic, hepatic, and renal tests consistent with guidelines. However, only 40% received 1 or more lipid tests. Monitoring was more frequent in specific subgroups, likely reflecting better clinic attendance or clinician perception of higher susceptibility to toxicities.