학술논문
A noncoding regulatory variant in IKZF1 increases acute lymphoblastic leukemia risk in Hispanic/Latino children
Document Type
article
Author
de Smith, Adam J; Wahlster, Lara; Jeon, Soyoung; Kachuri, Linda; Black, Susan; Langie, Jalen; Cato, Liam D; Nakatsuka, Nathan; Chan, Tsz-Fung; Xia, Guangze; Mazumder, Soumyaa; Yang, Wenjian; Gazal, Steven; Eng, Celeste; Hu, Donglei; Burchard, Esteban González; Ziv, Elad; Metayer, Catherine; Mancuso, Nicholas; Yang, Jun J; Ma, Xiaomei; Wiemels, Joseph L; Yu, Fulong; Chiang, Charleston WK; Sankaran, Vijay G
Source
Cell Genomics. 4(4)
Subject
Language
Abstract
Hispanic/Latino children have the highest risk of acute lymphoblastic leukemia (ALL) in the US compared to other racial/ethnic groups, yet the basis of this remains incompletely understood. Through genetic fine-mapping analyses, we identified a new independent childhood ALL risk signal near IKZF1 in self-reported Hispanic/Latino individuals, but not in non-Hispanic White individuals, with an effect size of ∼1.44 (95% confidence interval = 1.33-1.55) and a risk allele frequency of ∼18% in Hispanic/Latino populations and