학술논문
Symptoms Have Modest Accuracy in Detecting Endoscopic and Histologic Remission in Adults With Eosinophilic Esophagitis
Document Type
article
Author
Safroneeva, Ekaterina; Straumann, Alex; Coslovsky, Michael; Zwahlen, Marcel; Kuehni, Claudia E; Panczak, Radoslaw; Haas, Nadine A; Alexander, Jeffrey A; Dellon, Evan S; Gonsalves, Nirmala; Hirano, Ikuo; Leung, John; Bussmann, Christian; Collins, Margaret H; Newbury, Robert O; De Petris, Giovanni; Smyrk, Thomas C; Woosley, John T; Yan, Pu; Yang, Guang-Yu; Romero, Yvonne; Katzka, David A; Furuta, Glenn T; Gupta, Sandeep K; Aceves, Seema S; Chehade, Mirna; Spergel, Jonathan M; Schoepfer, Alain M; Group, International Eosinophilic Esophagitis Activity Index Study; Achem, Sami R; Arora, Amindra S; Alpan, Oral; Armstrong, David; Attwood, Stephen E; Butterfield, Joseph H; Crowell, Michael D; DeVault, Kenneth R; Drouin, Eric; Enav, Benjamin; Enders, Felicity T; Fleischer, David E; Foxx-Orenstein, Amy; Francis, Dawn L; Guyatt, Gordon H; Harris, Lucinda A; Kagalwalla, Amir F; Kita, Hirohito; Krishna, Murli; Lee, James J; Lewis, John C; Lim, Kaiser; Locke, G Richard; Murray, Joseph A; Nguyen, Cuong C; Orbelo, Diana M; Pasha, Shabana F; Ramirez, Francisco C; Sheikh, Javed; Umar, Sarah B; Weiler, Catherine R; Wo, John M; Wu, Tsung-Teh; Yost, Kathleen J
Source
Gastroenterology. 150(3)
Subject
Language
Abstract
Background & aimsIt is not clear whether symptoms alone can be used to estimate the biologic activity of eosinophilic esophagitis (EoE). We aimed to evaluate whether symptoms can be used to identify patients with endoscopic and histologic features of remission.MethodsBetween April 2011 and June 2014, we performed a prospective, observational study and recruited 269 consecutive adults with EoE (67% male; median age, 39 years old) in Switzerland and the United States. Patients first completed the validated symptom-based EoE activity index patient-reported outcome instrument and then underwent esophagogastroduodenoscopy with esophageal biopsy collection. Endoscopic and histologic findings were evaluated with a validated grading system and standardized instrument, respectively. Clinical remission was defined as symptom score