학술논문

Effects of early corticosteroid treatment on plasma SARS-associated Coronavirus RNA concentrations in adult patients

Document Type

article

Author

Lee, Nelson; Chan, KC Allen; Hui, David S; Ng, Enders KO; Wu, Alan; Chiu, Rossa WK; Wong, Vincent WS; Chan, Paul KS; Wong, KT; Wong, Eric; Cockram, CS; Tam, John S; Sung, Joseph JY; Lo, YM Dennis

Source

Journal of Clinical Virology. 31(4)

Subject

Clinical Research
Pneumonia
Clinical Trials and Supportive Activities
Genetics
Infectious Diseases
Prevention
Lung
Emerging Infectious Diseases
6.1 Pharmaceuticals
Evaluation of treatments and therapeutic interventions
Infection
Good Health and Well Being
Adrenal Cortex Hormones
Adult
Coronavirus
Double-Blind Method
Humans
Prospective Studies
RNA
Viral
Severe acute respiratory syndrome-related coronavirus
Severe Acute Respiratory Syndrome
Viral Load
Microbiology
Clinical Sciences
Medical Microbiology
Virology

Language

Abstract

BackgroundThe effect of corticosteroid treatment on the viral load of Severe Acute Respiratory Syndrome (SARS) patients is unknown.ObjectiveTo compare the plasma SARS-CoV RNA concentrations in ribavirin-treated patients who received early hydrocortisone therapy with those who received placebo.Study designSerial plasma SARS-CoV RNA concentrations measured in the setting of a prospective, randomized double-blinded, placebo-controlled trial designed to assess the efficacy of "early" (

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