학술논문

Remdesivir for the prevention of invasive mechanical ventilation or death in COVID-19 - A post-hoc analysis of the Adaptive COVID-19 Treatment Trial-1 Cohort Data
Document Type
article
Source
Clinical Infectious Diseases. 74(7)
Subject
Clinical Research
Prevention
Clinical Trials and Supportive Activities
Lung
Neurodegenerative
Good Health and Well Being
Adenosine Monophosphate
Alanine
Antiviral Agents
Clinical Trials as Topic
Humans
Respiration
Artificial
SARS-CoV-2
COVID-19 Drug Treatment
COVID-19
remdesivir
ACTT-1
Biological Sciences
Medical and Health Sciences
Microbiology
Language
Abstract
This post hoc analysis of the Adaptive Coronavirus Disease 2019 (COVID-19) Treatment Trial-1 (ACTT-1) shows a treatment effect of remdesivir (RDV) on progression to invasive mechanical ventilation (IMV) or death. Additionally, we create a risk profile that better predicts progression than baseline oxygen requirement alone. The highest risk group derives the greatest treatment effect from RDV.