부산대학교 도서관

Two recent studies have shown a woman’s bone mineral density (BMD) (a composite measure of exposure to many different factorsthroughout one’s lifetime) predicts breast cancer. In a prospective cohort study, we examined whether hip BMD was associated withbreast cancer risk among 8203 postmenopausal women. During an average follow-up of 3.7 years, 131 incident breast cancer cases (102 invasive) were identified. Cox proportional hazards models were used to obtain estimates of the relative risk of breast cancer. Our resultsdemonstrate an increase in breast cancer risk among women with higher BMD. Independent of age, geographic area, and body mass index,relative to the lowest BMD quartile the risk of breast cancer (95% confidence interval) by increasing quartile was 1.9 (1.1, 3.2), 1.5 (0.8,2.6), and 1.5 (0.8, 2.7), respectively. An examination of other factors important in determining BMD may help explain the positive association between BMD and breast cancer. © 2001 Elsevier Science Inc. All rights reserved