학술논문
Passive and active immunity in infants born to mothers with SARS-CoV-2 infection during pregnancy: prospective cohort study
Document Type
article
Author
Song, Dongli; Prahl, Mary; Gaw, Stephanie L; Narasimhan, Sudha Rani; Rai, Daljeet S; Huang, Angela; Flores, Claudia V; Lin, Christine Y; Jigmeddagva, Unurzul; Wu, Alan; Warrier, Lakshmi; Levan, Justine; Nguyen, Catherine BT; Callaway, Perri; Farrington, Lila; Acevedo, Gonzalo R; Gonzalez, Veronica J; Vaaben, Anna; Nguyen, Phuong; Atmosfera, Elda; Marleau, Constance; Anderson, Christina; Misra, Sonya; Stemmle, Monica; Cortes, Maria; McAuley, Jennifer; Metz, Nicole; Patel, Rupalee; Nudelman, Matthew; Abraham, Susan; Byrne, James; Jegatheesan, Priya
Source
BMJ Open. 11(7)
Subject
Language
Abstract
ObjectiveTo investigate maternal immunoglobulins' (IgM, IgG) response to SARS-CoV-2 infection during pregnancy and IgG transplacental transfer, to characterise neonatal antibody response to SARS-CoV-2 infection, and to longitudinally follow actively and passively acquired antibodies in infants.DesignA prospective observational study.SettingPublic healthcare system in Santa Clara County (California, USA).ParticipantsWomen with symptomatic or asymptomatic SARS-CoV-2 infection during pregnancy and their infants were enrolled between 15 April 2020 and 31 March 2021.OutcomesSARS-CoV-2 serology analyses in the cord and maternal blood at delivery and longitudinally in infant blood between birth and 28 weeks of life.ResultsOf 145 mothers who tested positive for SARS-CoV-2 during pregnancy, 86 had symptomatic infections: 78 with mild-moderate symptoms, and 8 with severe-critical symptoms. The seropositivity rates of the mothers at delivery was 65% (95% CI 0.56% to 0.73%) and the cord blood was 58% (95% CI 0.49% to 0.66%). IgG levels significantly correlated between the maternal and cord blood (Rs=0.93, p