학술논문
Sequence and function of the two P domain potassium channels: implications of an emerging superfamily.
Document Type
article
Author
Source
Journal of molecular medicine (Berlin, Germany). 76(1)
Subject
Language
Abstract
A new superfamily of K+ channels has emerged in the past 2 years. Notable for possessing two pore-forming P domains in each subunit, members of the superfamily have been recognized through phylogeny from micro-organisms to humans. Four subfamilies of two P domain channels have been isolated thus far; among these are the first cloned examples of outward rectifier and open rectifier (or leak) K+ channels. The two P domain K+ channels offer a new perspective from which to glimpse the molecular basis for function and dysfunction of K+-selective ion channels.