학술논문
Instrumental validation of free water, peak‐width of skeletonized mean diffusivity, and white matter hyperintensities: MarkVCID neuroimaging kits
Document Type
article
Author
Maillard, Pauline; Lu, Hanzhang; Arfanakis, Konstantinos; Gold, Brian T; Bauer, Christopher E; Zachariou, Valentinos; Stables, Lara; Wang, Danny JJ; Jann, Kay; Seshadri, Sudha; Duering, Marco; Hillmer, Laura J; Rosenberg, Gary A; Snoussi, Haykel; Sepehrband, Farshid; Habes, Mohamad; Singh, Baljeet; Kramer, Joel H; Corriveau, Roderick A; Singh, Herpreet; Schwab, Kristin; Helmer, Karl G; Greenberg, Steven M; Caprihan, Arvind; DeCarli, Charles; Satizabal, Claudia L; Consortium, for the MarkVCID
Source
Alzheimer's & Dementia Diagnosis Assessment & Disease Monitoring. 14(1)
Subject
Language
Abstract
IntroductionTo describe the protocol and findings of the instrumental validation of three imaging-based biomarker kits selected by the MarkVCID consortium: free water (FW) and peak width of skeletonized mean diffusivity (PSMD), both derived from diffusion tensor imaging (DTI), and white matter hyperintensity (WMH) volume derived from fluid attenuation inversion recovery and T1-weighted imaging.MethodsThe instrumental validation of imaging-based biomarker kits included inter-rater reliability among participating sites, test-retest repeatability, and inter-scanner reproducibility across three types of magnetic resonance imaging (MRI) scanners using intra-class correlation coefficients (ICC).ResultsThe three biomarkers demonstrated excellent inter-rater reliability (ICC >0.94, P-values 0.98, P-values 0.98, P-values