학술논문
Association of the IFNL4-ΔG Allele With Impaired Spontaneous Clearance of Hepatitis C Virus
Document Type
article
Author
Aka, Peter V; Kuniholm, Mark H; Pfeiffer, Ruth M; Wang, Alan S; Tang, Wei; Chen, Sabrina; Astemborski, Jacquie; Plankey, Michael; Villacres, Maria C; Peters, Marion G; Desai, Seema; Seaberg, Eric C; Edlin, Brian R; Strickler, Howard D; Thomas, David L; Prokunina-Olsson, Ludmila; Sharp, Gerald B; O'Brien, Thomas R
Source
The Journal of Infectious Diseases. 209(3)
Subject
Language
Abstract
Interferon lambda 4 protein can be generated in IFNL4-ΔG carriers but not IFNL4-TT homozygotes. We studied 890 anti-hepatitis C virus (HCV)-positive participants in the Women's Interagency HIV Study. Among blacks (n = 555), HCV was more often cleared for those with genotype IFNL4-TT/TT (32.6%; odds ratio [OR], 3.59; P = 3.3 × 10(-5)) than IFNL4-TT/ΔG (11.3%; OR, 0.95; P = .86) or IFNL4-ΔG/ΔG (11.9%; referent). Pooling these data with published results in blacks (n = 1678), ORs were 3.84 (P = 8.6 × 10(-14)) for IFNL4-TT/TT and 1.44 (P = .03) IFNL4-TT/ΔG, and the area under the curve was 0.64 for IFNL4-ΔG genotype and 0.61 for rs12979860 (IL28B). IFNL4-ΔG is strongly associated with impaired spontaneous HCV clearance.