학술논문
Genome-wide association study and functional characterization identifies candidate genes for insulin-stimulated glucose uptake
Document Type
article
Author
Williamson, Alice; Norris, Dougall M; Yin, Xianyong; Broadaway, K Alaine; Moxley, Anne H; Vadlamudi, Swarooparani; Wilson, Emma P; Jackson, Anne U; Ahuja, Vasudha; Andersen, Mette K; Arzumanyan, Zorayr; Bonnycastle, Lori L; Bornstein, Stefan R; Bretschneider, Maxi P; Buchanan, Thomas A; Chang, Yi-Cheng; Chuang, Lee-Ming; Chung, Ren-Hua; Clausen, Tine D; Damm, Peter; Delgado, Graciela E; de Mello, Vanessa D; Dupuis, Josée; Dwivedi, Om P; Erdos, Michael R; Silva, Lilian Fernandes; Frayling, Timothy M; Gieger, Christian; Goodarzi, Mark O; Guo, Xiuqing; Gustafsson, Stefan; Hakaste, Liisa; Hammar, Ulf; Hatem, Gad; Herrmann, Sandra; Højlund, Kurt; Horn, Katrin; Hsueh, Willa A; Hung, Yi-Jen; Hwu, Chii-Min; Jonsson, Anna; Kårhus, Line L; Kleber, Marcus E; Kovacs, Peter; Lakka, Timo A; Lauzon, Marie; Lee, I-Te; Lindgren, Cecilia M; Lindström, Jaana; Linneberg, Allan; Liu, Ching-Ti; Luan, Jian’an; Aly, Dina Mansour; Mathiesen, Elisabeth; Moissl, Angela P; Morris, Andrew P; Narisu, Narisu; Perakakis, Nikolaos; Peters, Annette; Prasad, Rashmi B; Rodionov, Roman N; Roll, Kathryn; Rundsten, Carsten F; Sarnowski, Chloé; Savonen, Kai; Scholz, Markus; Sharma, Sapna; Stinson, Sara E; Suleman, Sufyan; Tan, Jingyi; Taylor, Kent D; Uusitupa, Matti; Vistisen, Dorte; Witte, Daniel R; Walther, Romy; Wu, Peitao; Xiang, Anny H; Zethelius, Björn; Ahlqvist, Emma; Bergman, Richard N; Chen, Yii-Der Ida; Collins, Francis S; Fall, Tove; Florez, Jose C; Fritsche, Andreas; Grallert, Harald; Groop, Leif; Hansen, Torben; Koistinen, Heikki A; Komulainen, Pirjo; Laakso, Markku; Lind, Lars; Loeffler, Markus; März, Winfried; Meigs, James B; Raffel, Leslie J; Rauramaa, Rainer; Rotter, Jerome I; Schwarz, Peter EH; Stumvoll, Michael
Source
Nature Genetics. 55(6)
Subject
Language
Abstract
Distinct tissue-specific mechanisms mediate insulin action in fasting and postprandial states. Previous genetic studies have largely focused on insulin resistance in the fasting state, where hepatic insulin action dominates. Here we studied genetic variants influencing insulin levels measured 2 h after a glucose challenge in >55,000 participants from three ancestry groups. We identified ten new loci (P