학술논문
Association of Vasopressor Choice with Clinical and Functional Outcomes Following Moderate to Severe Traumatic Brain Injury: A TRACK-TBI Study
Document Type
article
Author
Toro, Camilo; Temkin, Nancy; Barber, Jason; Manley, Geoffrey; Jain, Sonia; Ohnuma, Tetsu; Komisarow, Jordan; Foreman, Brandon; Korley, Frederick K; Vavilala, Monica S; Laskowitz, Daniel T; Mathew, Joseph P; Hernandez, Adrian; Sampson, John; James, Michael L; Goldstein, Benjamin A; Markowitz, Amy J; Krishnamoorthy, Vijay
Source
Neurocritical Care. 36(1)
Subject
Language
Abstract
BackgroundEarly hypotension following moderate to severe traumatic brain injury (TBI) is associated with increased mortality and poor long-term outcomes. Current guidelines suggest the use of intravenous vasopressors to support blood pressure following TBI; however, guidelines do not specify vasopressor type, resulting in variation in clinical practice. Minimal data are available to guide clinicians on optimal early vasopressor choice to support blood pressure following TBI. Therefore, we conducted a multicenter study to examine initial vasopressor choice for the support of blood pressure following TBI and its association with clinical and functional outcomes after injury.MethodsWe conducted a retrospective cohort study of patients enrolled in the transforming research and clinical knowledge in traumatic brain injury (TRACK-TBI) study, an 18-center prospective cohort study of patients with TBI evaluated in participating level I trauma centers. We examined adults with moderate to severe TBI (defined as Glasgow Coma Scale score