학술논문
Demographic and clinical characteristics associated with variations in antibody response to BNT162b2 COVID-19 vaccination among healthcare workers at an academic medical centre: a longitudinal cohort analysis
Document Type
article
Author
Ebinger, Joseph E; Joung, Sandy; Liu, Yunxian; Wu, Min; Weber, Brittany; Claggett, Brian; Botting, Patrick G; Sun, Nancy; Driver, Matthew; Kao, Yu Hung; Khuu, Briana; Wynter, Timothy; Nguyen, Trevor-Trung; Alotaibi, Mona; Prostko, John C; Frias, Edwin C; Stewart, James L; Goodridge, Helen S; Chen, Peter; Jordan, Stanley C; Jain, Mohit; Sharma, Sonia; Fert-Bober, Justyna; Van Eyk, Jennifer E; Minissian, Margo B; Arditi, Moshe; Melmed, Gil Y; Braun, Jonathan G; McGovern, Dermot PB; Cheng, Susan; Sobhani, Kimia
Source
BMJ Open. 12(5)
Subject
Language
Abstract
ObjectivesWe sought to understand the demographic and clinical factors associated with variations in longitudinal antibody response following completion of two-dose regiment of BNT162b2 vaccination.DesignThis study is a 10-month longitudinal cohort study of healthcare workers and serially measured anti-spike protein IgG (IgG-S) antibody levels using mixed linear models to examine their associations with participant characteristics.SettingA large, multisite academic medical centre in Southern California, USA.ParticipantsA total of 843 healthcare workers met inclusion criteria including completion of an initial two-dose course of BNT162b2 vaccination, complete clinical history and at least two blood samples for analysis. Patients had an average age of 45±13 years, were 70% female and 7% with prior SARS-CoV-2 infection.ResultsVaccine-induced IgG-S levels remained in the positive range for 99.6% of individuals up to 10 months after initial two-dose vaccination. Prior SARS-CoV-2 infection was the primary correlate of sustained higher postvaccination IgG-S levels (partial R2=0.133), with a 1.74±0.11 SD higher IgG-S response (p