학술논문
Whole-genome association analysis of treatment response in obsessive-compulsive disorder.
Document Type
article
Author
Qin, H; Samuels, JF; Wang, Y; Zhu, Y; Grados, MA; Riddle, MA; Greenberg, BD; Knowles, JA; Fyer, AJ; McCracken, JT; Murphy, DL; Rasmussen, SA; Cullen, BA; Piacentini, J; Geller, D; Stewart, SE; Pauls, D; Bienvenu, OJ; Goes, FS; Maher, B; Pulver, AE; Valle, D; Lange, C; Mattheisen, M; McLaughlin, NC; Liang, K-Y; Nurmi, EL; Askland, KD; Nestadt, G; Shugart, YY
Source
Molecular psychiatry. 21(2)
Subject
Language
Abstract
Up to 30% of patients with obsessive-compulsive disorder (OCD) exhibit an inadequate response to serotonin reuptake inhibitors (SRIs). To date, genetic predictors of OCD treatment response have not been systematically investigated using genome-wide association study (GWAS). To identify specific genetic variations potentially influencing SRI response, we conducted a GWAS study in 804 OCD patients with information on SRI response. SRI response was classified as 'response' (n=514) or 'non-response' (n=290), based on self-report. We used the more powerful Quasi-Likelihood Score Test (the MQLS test) to conduct a genome-wide association test correcting for relatedness, and then used an adjusted logistic model to evaluate the effect size of the variants in probands. The top single-nucleotide polymorphism (SNP) was rs17162912 (P=1.76 × 10(-8)), which is near the DISP1 gene on 1q41-q42, a microdeletion region implicated in neurological development. The other six SNPs showing suggestive evidence of association (P