학술논문
Genome-wide meta-analysis of macronutrient intake of 91,114 European ancestry participants from the cohorts for heart and aging research in genomic epidemiology consortium
Document Type
article
Author
Merino, Jordi; Dashti, Hassan S; Li, Sherly X; Sarnowski, Chloé; Justice, Anne E; Graff, Misa; Papoutsakis, Constantina; Smith, Caren E; Dedoussis, George V; Lemaitre, Rozenn N; Wojczynski, Mary K; Männistö, Satu; Ngwa, Julius S; Kho, Minjung; Ahluwalia, Tarunveer S; Pervjakova, Natalia; Houston, Denise K; Bouchard, Claude; Huang, Tao; Orho-Melander, Marju; Frazier-Wood, Alexis C; Mook-Kanamori, Dennis O; Pérusse, Louis; Pennell, Craig E; de Vries, Paul S; Voortman, Trudy; Li, Olivia; Kanoni, Stavroula; Rose, Lynda M; Lehtimäki, Terho; Zhao, Jing Hua; Feitosa, Mary F; Luan, Jian’an; McKeown, Nicola M; Smith, Jennifer A; Hansen, Torben; Eklund, Niina; Nalls, Mike A; Rankinen, Tuomo; Huang, Jinyan; Hernandez, Dena G; Schulz, Christina-Alexandra; Manichaikul, Ani; Li-Gao, Ruifang; Vohl, Marie-Claude; Wang, Carol A; van Rooij, Frank JA; Shin, Jean; Kalafati, Ioanna P; Day, Felix; Ridker, Paul M; Kähönen, Mika; Siscovick, David S; Langenberg, Claudia; Zhao, Wei; Astrup, Arne; Knekt, Paul; Garcia, Melissa; Rao, DC; Qi, Qibin; Ferrucci, Luigi; Ericson, Ulrika; Blangero, John; Hofman, Albert; Pausova, Zdenka; Mikkilä, Vera; Wareham, Nick J; Kardia, Sharon LR; Pedersen, Oluf; Jula, Antti; Curran, Joanne E; Zillikens, M Carola; Viikari, Jorma S; Forouhi, Nita G; Ordovás, José M; Lieske, John C; Rissanen, Harri; Uitterlinden, André G; Raitakari, Olli T; Kiefte-de Jong, Jessica C; Dupuis, Josée; Rotter, Jerome I; North, Kari E; Scott, Robert A; Province, Michael A; Perola, Markus; Cupples, L Adrienne; Turner, Stephen T; Sørensen, Thorkild IA; Salomaa, Veikko; Liu, Yongmei; Sung, Yun J; Qi, Lu; Bandinelli, Stefania; Rich, Stephen S; de Mutsert, Renée; Tremblay, Angelo; Oddy, Wendy H; Franco, Oscar H; Paus, Tomas
Source
Molecular Psychiatry. 24(12)
Subject
Language
Abstract
Macronutrient intake, the proportion of calories consumed from carbohydrate, fat, and protein, is an important risk factor for metabolic diseases with significant familial aggregation. Previous studies have identified two genetic loci for macronutrient intake, but incomplete coverage of genetic variation and modest sample sizes have hindered the discovery of additional loci. Here, we expanded the genetic landscape of macronutrient intake, identifying 12 suggestively significant loci (P