학술논문
Risk-reducing mastectomy and breast cancer mortality in women with a BRCA1 or BRCA2 pathogenic variant: an international analysis
Document Type
article
Author
Metcalfe, Kelly; Huzarski, Tomasz; Gronwald, Jacek; Kotsopoulos, Joanne; Kim, Raymond; Moller, Pal; Pal, Tuya; Aeilts, Amber; Eisen, Andrea; Karlan, Beth; Bordeleau, Louise; Tung, Nadine; Olopade, Olufunmilayo; Zakalik, Dana; Singer, Christian F; Foulkes, William; Couch, Fergus; Neuhausen, Susan L; Eng, Charis; Sun, Ping; Lubinski, Jan; Narod, Steven A
Source
British Journal of Cancer. 130(2)
Subject
Language
Abstract
BackgroundRisk-reducing mastectomy (RRM) is offered to women with a BRCA1 or BRCA2 pathogenic variant, however, there are limited data on the impact on breast cancer mortality.MethodsParticipants were identified from a registry of women with BRCA1/2 pathogenic variants. We used a pseudo-randomised trial design and matched one woman with a RRM to one woman without a RRM on year of birth, gene, and country. We estimated the hazard ratio (HR) and 95% confidence intervals (CI) for dying of breast cancer in the follow-up period.ResultsThere were 1654 women included; 827 assigned to the RRM arm and 827 assigned to the control arm. After a mean follow-up of 6.3 years, there were 20 incident breast cancers (including 15 occult cancers) and two breast cancer deaths in the RRM arm, and 100 incident breast cancers and 7 breast cancer deaths in the control arm (HR = 0.26; 95% CI 0.05-1.35; p = 0.11). The probability of dying of breast cancer within 15 years after RRM was 0.95%.ConclusionsIn women with a BRCA1 or BRCA2 pathogenic variant, RRM reduces the risk of breast cancer, and the probability of dying of breast cancer is low.