학술논문
Cerebrospinal fluid, plasma, and saliva in the BioFIND study: Relationships among biomarkers and Parkinson's disease Features
Document Type
article
Author
Goldman, Jennifer G; Andrews, Howard; Amara, Amy; Naito, Anna; Alcalay, Roy N; Shaw, Leslie M; Taylor, Peggy; Xie, Tao; Tuite, Paul; Henchcliffe, Claire; Hogarth, Penelope; Frank, Samuel; Saint‐Hilaire, Marie‐Helene; Frasier, Mark; Arnedo, Vanessa; Reimer, Alyssa N; Sutherland, Margaret; Swanson‐Fischer, Christine; Gwinn, Katrina; Discovery, The Fox Investigation of New Biomarker; Kang, Un Jung
Source
Movement Disorders. 33(2)
Subject
Language
Abstract
ObjectiveExamine relationships among neurodegenerative biomarkers and PD motor and nonmotor symptoms.BackgroundCSF alpha-synuclein is decreased in PD versus healthy controls, but whether plasma and saliva alpha-synuclein differentiate these groups is controversial. Correlations of alpha-synuclein among biofluids (CSF, plasma, saliva) or biomarkers (eg, beta-amyloid, tau [total, phosphorylated]) are not fully understood. The relationships of these biomarkers with PD clinical features remain unclear.MethodsBioFIND, a cross-sectional, observational study, examines clinical and biomarker characteristics in moderate-advanced PD and matched healthy controls. We compared alpha-synuclein concentrations across diagnosis, biofluids, and CSF biomarkers. Correlations of CSF biomarkers and MDS-UPDRS, motor phenotype, MoCA, and rapid eye movement sleep behavior disorder questionnaire scores in PD were examined.ResultsCSF alpha-synuclein was lower in PD versus controls (P = .01), controlling for age, gender, and education. Plasma and saliva alpha-synuclein did not differ between PD and controls, and alpha-synuclein did not significantly correlate among biofluids. CSF beta-amyloid1-42 was lower in PD versus controls (P