학술논문
Dose to the Contralateral Breast From Radiotherapy and Risk of Second Primary Breast Cancer in the WECARE Study
Document Type
article
Author
Stovall, Marilyn; Smith, Susan A; Langholz, Bryan M; Boice, John D; Shore, Roy E; Andersson, Michael; Buchholz, Thomas A; Capanu, Marinela; Bernstein, Leslie; Lynch, Charles F; Malone, Kathleen E; Anton-Culver, Hoda; Haile, Robert W; Rosenstein, Barry S; Reiner, Anne S; Thomas, Duncan C; Bernstein, Jonine L; Group, WECARE Study Collaborative
Source
International Journal of Radiation Oncology • Biology • Physics. 72(4)
Subject
Language
Abstract
PurposeTo quantify the risk of second primary breast cancer in the contralateral breast (CB) after radiotherapy (RT) for first breast cancer.Methods and materialsThe study population included participants in the Women's Environmental, Cancer, and Radiation Epidemiology study: 708 cases (women with asynchronous bilateral breast cancer) and 1399 controls (women with unilateral breast cancer) counter-matched on radiation treatment. Participants were 1.0 Gy of absorbed dose to the specific quadrant of the CB had a 2.5-fold greater risk for CB cancer than unexposed women (RR = 2.5, 95% CI 1.4-4.5). No excess risk was observed in women >40 years of age. Women 5 years had a RR of 3.0 (95% CI 1.1-8.1), and the dose response was significant (excess RR per Gy of 1.0, 95% CI 0.1-3.0).ConclusionsWomen 1.0 Gy to the CB had an elevated, long-term risk of developing a second primary CB cancer. The risk is inversely related to age at exposure and is dose dependent.