학술논문
Features of acute COVID-19 associated with post-acute sequelae of SARS-CoV-2 phenotypes: results from the IMPACC study
Document Type
article
Author
McEnaney, Kerry; Barton, Brenda; Lentucci, Claudia; Saluvan, Mehmet; Chang, Ana C; Hoch, Annmarie; Albert, Marisa; Shaheen, Tanzia; Kho, Alvin T; Thomas, Sanya; Chen, Jing; Murphy, Maimouna D; Cooney, Mitchell; Hayati, Arash Nemati; Bryant, Robert; Abraham, James; Presnell, Scott; Jancsyk, Tomasz; Maguire, Cole; Lee, Brian; Fourati, Slim; Esserman, Denise A; Guan, Leying; Gygi, Jeremy; Pawar, Shrikant; Brito, Anderson; Fragiadakis, Gabriela K; Patel, Ravi; Tebbutt, Scott J; Overton, James A; Vita, Randi; Westendorf, Kerstin; Thyagarajan, Rama V; Rousseau, Justin F; Wylie, Dennis; Triplett, Todd A; Kojic, Erna; Chinthrajah, Sharon; Ahuja, Neera; Rogers, Angela J; Artandi, Maja; Yendewa, George; Powell, Debra L; Kim, James N; Simmons, Brent; Goonewardene, I Michael; Smith, Cecilia M; Martens, Mark; Sherman, Amy C; Walsh, Stephen R; Issa, Nicolas C; Salehi-Rad, Ramin; Dela Cruz, Charles; Farhadian, Shelli; Iwasaki, Akiko; Ko, Albert I; Anderson, Evan J; Mehta, Aneesh K; Sevransky, Jonathan E; Leligdowicz, Aleksandra; Matthay, Michael A; Singer, Jonathan P; Kangelaris, Kirsten N; Hendrickson, Carolyn M; Krummel, Matthew F; Woodruff, Prescott G; Anderson, Matthew L; Guirgis, Faheem W; Drevets, Douglas A; Brown, Brent R; Siegel, Sarah AR; Lu, Zhengchun; Mosier, Jarrod; Kimura, Hiroki; Khor, Bernard; Rahman, Adeeb; Stadlbauer, Daniel; Dutta, Jayeeta; Gonzalez-Reiche, Ana Silvia; van de Guchte, Adriana; Carreño, Juan Manuel; Singh, Gagandeep; Raskin, Ariel; Tcheou, Johnstone; Bielak, Dominika; Kawabata, Hisaaki; Xie, Hui; Kelly, Geoffrey; Patel, Manishkumar; Nie, Kai; Yellin, Temima; Fried, Miriam; Sullivan, Leeba; Morris, Sara; Sieg, Scott; van Zalm, Patrick; Fatou, Benoit; Mendez, Kevin; Lasky-Su, Jessica; Hutton, Scott R
Source
Nature Communications. 15(1)
Subject
Language
Abstract
Post-acute sequelae of SARS-CoV-2 (PASC) is a significant public health concern. We describe Patient Reported Outcomes (PROs) on 590 participants prospectively assessed from hospital admission for COVID-19 through one year after discharge. Modeling identified 4 PRO clusters based on reported deficits (minimal, physical, mental/cognitive, and multidomain), supporting heterogenous clinical presentations in PASC, with sub-phenotypes associated with female sex and distinctive comorbidities. During the acute phase of disease, a higher respiratory SARS-CoV-2 viral burden and lower Receptor Binding Domain and Spike antibody titers were associated with both the physical predominant and the multidomain deficit clusters. A lower frequency of circulating B lymphocytes by mass cytometry (CyTOF) was observed in the multidomain deficit cluster. Circulating fibroblast growth factor 21 (FGF21) was significantly elevated in the mental/cognitive predominant and the multidomain clusters. Future efforts to link PASC to acute anti-viral host responses may help to better target treatment and prevention of PASC.