학술논문
Association of day-of-injury plasma glial fibrillary acidic protein concentration and six-month posttraumatic stress disorder in patients with mild traumatic brain injury
Document Type
article
Author
Kulbe, Jacqueline R; Jain, Sonia; Nelson, Lindsay D; Korley, Frederick K; Mukherjee, Pratik; Sun, Xiaoying; Okonkwo, David O; Giacino, Joseph T; Vassar, Mary J; Robertson, Claudia S; McCrea, Michael A; Wang, Kevin KW; Temkin, Nancy; Mac Donald, Christine L; Taylor, Sabrina R; Ferguson, Adam R; Markowitz, Amy J; Diaz-Arrastia, Ramon; Manley, Geoffrey T; Stein, Murray B
Source
Neuropsychopharmacology. 47(13)
Subject
Language
Abstract
Several proteins have proven useful as blood-based biomarkers to assist in evaluation and management of traumatic brain injury (TBI). The objective of this study was to determine whether two day-of-injury blood-based biomarkers are predictive of posttraumatic stress disorder (PTSD). We used data from 1143 individuals with mild TBI (mTBI; defined as admission Glasgow Coma Scale [GCS] score 13-15) enrolled in TRACK-TBI, a prospective longitudinal study of level 1 trauma center patients. Plasma glial fibrillary acidic protein (GFAP) and serum high sensitivity C-reactive protein (hsCRP) were measured from blood collected within 24 h of injury. Two hundred and twenty-seven (19.9% of) patients had probable PTSD (PCL-5 score ≥ 33) at 6 months post-injury. GFAP levels were positively associated (Spearman's rho = 0.35, p