학술논문
Serum lipids are associated with nonalcoholic fatty liver disease: a pilot case-control study in Mexico
Document Type
article
Author
Flores, Yvonne N; Amoon, Aryana T; Su, Baolong; Velazquez-Cruz, Rafael; Ramírez-Palacios, Paula; Salmerón, Jorge; Rivera-Paredez, Berenice; Sinsheimer, Janet S; Lusis, Aldons J; Huertas-Vazquez, Adriana; Saab, Sammy; Glenn, Beth A; May, Folasade P; Williams, Kevin J; Bastani, Roshan; Bensinger, Steven J
Source
Lipids in Health and Disease. 20(1)
Subject
Language
Abstract
BackgroundNonalcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disease and cirrhosis. NAFLD is mediated by changes in lipid metabolism and known risk factors include obesity, metabolic syndrome, and diabetes. The aim of this study was to better understand differences in the lipid composition of individuals with NAFLD compared to controls, by performing direct infusion lipidomics on serum biospecimens from a cohort study of adults in Mexico.MethodsA nested case-control study was conducted with a sample of 98 NAFLD cases and 100 healthy controls who are participating in an on-going, longitudinal study in Mexico. NAFLD cases were clinically confirmed using elevated liver enzyme tests and liver ultrasound or liver ultrasound elastography, after excluding alcohol abuse, and 100 controls were identified as having at least two consecutive normal alanine aminotransferase (ALT) and aspartate aminotransferase (AST) (