학술논문
DNA methylation and body mass index from birth to adolescence: meta-analyses of epigenome-wide association studies
Document Type
article
Author
Vehmeijer, Florianne OL; Küpers, Leanne K; Sharp, Gemma C; Salas, Lucas A; Lent, Samantha; Jima, Dereje D; Tindula, Gwen; Reese, Sarah; Qi, Cancan; Gruzieva, Olena; Page, Christian; Rezwan, Faisal I; Melton, Philip E; Nohr, Ellen; Escaramís, Geòrgia; Rzehak, Peter; Heiskala, Anni; Gong, Tong; Tuominen, Samuli T; Gao, Lu; Ross, Jason P; Starling, Anne P; Holloway, John W; Yousefi, Paul; Aasvang, Gunn Marit; Beilin, Lawrence J; Bergström, Anna; Binder, Elisabeth; Chatzi, Leda; Corpeleijn, Eva; Czamara, Darina; Eskenazi, Brenda; Ewart, Susan; Ferre, Natalia; Grote, Veit; Gruszfeld, Dariusz; Håberg, Siri E; Hoyo, Cathrine; Huen, Karen; Karlsson, Robert; Kull, Inger; Langhendries, Jean-Paul; Lepeule, Johanna; Magnus, Maria C; Maguire, Rachel L; Molloy, Peter L; Monnereau, Claire; Mori, Trevor A; Oken, Emily; Räikkönen, Katri; Rifas-Shiman, Sheryl; Ruiz-Arenas, Carlos; Sebert, Sylvain; Ullemar, Vilhelmina; Verduci, Elvira; Vonk, Judith M; Xu, Cheng-jian; Yang, Ivana V; Zhang, Hongmei; Zhang, Weiming; Karmaus, Wilfried; Dabelea, Dana; Muhlhausler, Beverly S; Breton, Carrie V; Lahti, Jari; Almqvist, Catarina; Jarvelin, Marjo-Riitta; Koletzko, Berthold; Vrijheid, Martine; Sørensen, Thorkild IA; Huang, Rae-Chi; Arshad, Syed Hasan; Nystad, Wenche; Melén, Erik; Koppelman, Gerard H; London, Stephanie J; Holland, Nina; Bustamante, Mariona; Murphy, Susan K; Hivert, Marie-France; Baccarelli, Andrea; Relton, Caroline L; Snieder, Harold; Jaddoe, Vincent WV; Felix, Janine F
Source
Genome Medicine. 12(1)
Subject
Language
Abstract
BackgroundDNA methylation has been shown to be associated with adiposity in adulthood. However, whether similar DNA methylation patterns are associated with childhood and adolescent body mass index (BMI) is largely unknown. More insight into this relationship at younger ages may have implications for future prevention of obesity and its related traits.MethodsWe examined whether DNA methylation in cord blood and whole blood in childhood and adolescence was associated with BMI in the age range from 2 to 18 years using both cross-sectional and longitudinal models. We performed meta-analyses of epigenome-wide association studies including up to 4133 children from 23 studies. We examined the overlap of findings reported in previous studies in children and adults with those in our analyses and calculated enrichment.ResultsDNA methylation at three CpGs (cg05937453, cg25212453, and cg10040131), each in a different age range, was associated with BMI at Bonferroni significance, P