학술논문
Sensitive detection of tumor mutations from blood and its application to immunotherapy prognosis
Document Type
article
Author
Source
Nature Communications. 12(1)
Subject
Language
Abstract
Cell-free DNA (cfDNA) is attractive for many applications, including detecting cancer, identifying the tissue of origin, and monitoring. A fundamental task underlying these applications is SNV calling from cfDNA, which is hindered by the very low tumor content. Thus sensitive and accurate detection of low-frequency mutations (