학술논문
Cross-cancer pleiotropic associations with lung cancer risk in African Americans
Document Type
article
Author
Source
Cancer Epidemiology Biomarkers & Prevention. 28(4)
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Language
Abstract
BackgroundIdentifying genetic variants with pleiotropic associations across multiple cancers can reveal shared biologic pathways. Prior pleiotropic studies have primarily focused on European-descent individuals. Yet population-specific genetic variation can occur, and potential pleiotropic associations among diverse racial/ethnic populations could be missed. We examined cross-cancer pleiotropic associations with lung cancer risk in African Americans.MethodsWe conducted a pleiotropic analysis among 1,410 African American lung cancer cases and 2,843 controls. We examined 36,958 variants previously associated (or in linkage disequilibrium) with cancer in prior genome-wide association studies. Logistic regression analyses were conducted, adjusting for age, sex, global ancestry, study site, and smoking status.ResultsWe identified three novel genomic regions significantly associated (FDR-corrected P