학술논문
Genome-wide association study identifies eight loci associated with blood pressure
Document Type
article
Author
Newton-Cheh, Christopher; Johnson, Toby; Gateva, Vesela; Tobin, Martin D; Bochud, Murielle; Coin, Lachlan; Najjar, Samer S; Zhao, Jing Hua; Heath, Simon C; Eyheramendy, Susana; Papadakis, Konstantinos; Voight, Benjamin F; Scott, Laura J; Zhang, Feng; Farrall, Martin; Tanaka, Toshiko; Wallace, Chris; Chambers, John C; Khaw, Kay-Tee; Nilsson, Peter; van der Harst, Pim; Polidoro, Silvia; Grobbee, Diederick E; Onland-Moret, N Charlotte; Bots, Michiel L; Wain, Louise V; Elliott, Katherine S; Teumer, Alexander; Luan, Jian'an; Lucas, Gavin; Kuusisto, Johanna; Burton, Paul R; Hadley, David; McArdle, Wendy L; Brown, Morris; Dominiczak, Anna; Newhouse, Stephen J; Samani, Nilesh J; Webster, John; Zeggini, Eleftheria; Beckmann, Jacques S; Bergmann, Sven; Lim, Noha; Song, Kijoung; Vollenweider, Peter; Waeber, Gerard; Waterworth, Dawn M; Yuan, Xin; Groop, Leif; Orho-Melander, Marju; Allione, Alessandra; Di Gregorio, Alessandra; Guarrera, Simonetta; Panico, Salvatore; Ricceri, Fulvio; Romanazzi, Valeria; Sacerdote, Carlotta; Vineis, Paolo; Barroso, Inês; Sandhu, Manjinder S; Luben, Robert N; Crawford, Gabriel J; Jousilahti, Pekka; Perola, Markus; Boehnke, Michael; Bonnycastle, Lori L; Collins, Francis S; Jackson, Anne U; Mohlke, Karen L; Stringham, Heather M; Valle, Timo T; Willer, Cristen J; Bergman, Richard N; Morken, Mario A; Döring, Angela; Gieger, Christian; Illig, Thomas; Meitinger, Thomas; Org, Elin; Pfeufer, Arne; Wichmann, H Erich; Kathiresan, Sekar; Marrugat, Jaume; O'Donnell, Christopher J; Schwartz, Stephen M; Siscovick, David S; Subirana, Isaac; Freimer, Nelson B; Hartikainen, Anna-Liisa; McCarthy, Mark I; O'Reilly, Paul F; Peltonen, Leena; Pouta, Anneli; de Jong, Paul E; Snieder, Harold; van Gilst, Wiek H; Clarke, Robert; Goel, Anuj; Hamsten, Anders; Peden, John F
Source
Nature Genetics. 41(6)
Subject
Language
Abstract
Elevated blood pressure is a common, heritable cause of cardiovascular disease worldwide. To date, identification of common genetic variants influencing blood pressure has proven challenging. We tested 2.5 million genotyped and imputed SNPs for association with systolic and diastolic blood pressure in 34,433 subjects of European ancestry from the Global BPgen consortium and followed up findings with direct genotyping (N ≤ 71,225 European ancestry, N ≤ 12,889 Indian Asian ancestry) and in silico comparison (CHARGE consortium, N = 29,136). We identified association between systolic or diastolic blood pressure and common variants in eight regions near the CYP17A1 (P = 7 × 10(-24)), CYP1A2 (P = 1 × 10(-23)), FGF5 (P = 1 × 10(-21)), SH2B3 (P = 3 × 10(-18)), MTHFR (P = 2 × 10(-13)), c10orf107 (P = 1 × 10(-9)), ZNF652 (P = 5 × 10(-9)) and PLCD3 (P = 1 × 10(-8)) genes. All variants associated with continuous blood pressure were associated with dichotomous hypertension. These associations between common variants and blood pressure and hypertension offer mechanistic insights into the regulation of blood pressure and may point to novel targets for interventions to prevent cardiovascular disease.