학술논문
Genome-wide association study of Tourette's syndrome.
Document Type
article
Author
Scharf, JM; Yu, D; Mathews, CA; Neale, BM; Stewart, SE; Fagerness, JA; Evans, P; Gamazon, E; Edlund, CK; Service, SK; Tikhomirov, A; Osiecki, L; Illmann, C; Pluzhnikov, A; Konkashbaev, A; Davis, LK; Han, B; Crane, J; Moorjani, P; Crenshaw, AT; Parkin, MA; Reus, VI; Lowe, TL; Rangel-Lugo, M; Chouinard, S; Dion, Y; Girard, S; Cath, DC; Smit, JH; King, RA; Fernandez, TV; Leckman, JF; Kidd, KK; Kidd, JR; Pakstis, AJ; State, MW; Herrera, LD; Romero, R; Fournier, E; Sandor, P; Barr, CL; Phan, N; Gross-Tsur, V; Benarroch, F; Pollak, Y; Budman, CL; Bruun, RD; Erenberg, G; Naarden, AL; Lee, PC; Weiss, N; Kremeyer, B; Berrío, GB; Campbell, DD; Cardona Silgado, JC; Ochoa, WC; Mesa Restrepo, SC; Muller, H; Valencia Duarte, AV; Lyon, GJ; Leppert, M; Morgan, J; Weiss, R; Grados, MA; Anderson, K; Davarya, S; Singer, H; Walkup, J; Jankovic, J; Tischfield, JA; Heiman, GA; Gilbert, DL; Hoekstra, PJ; Robertson, MM; Kurlan, R; Liu, C; Gibbs, JR; Singleton, A; North American Brain Expression Consortium; Hardy, J; UK Human Brain Expression Database; Strengman, E; Ophoff, RA; Wagner, M; Moessner, R; Mirel, DB; Posthuma, D; Sabatti, C; Eskin, E; Conti, DV; Knowles, JA; Ruiz-Linares, A; Rouleau, GA; Purcell, S; Heutink, P; Oostra, BA; McMahon, WM; Freimer, NB; Cox, NJ; Pauls, DL
Source
Molecular psychiatry. 18(6)
Subject
Language
Abstract
Tourette's syndrome (TS) is a developmental disorder that has one of the highest familial recurrence rates among neuropsychiatric diseases with complex inheritance. However, the identification of definitive TS susceptibility genes remains elusive. Here, we report the first genome-wide association study (GWAS) of TS in 1285 cases and 4964 ancestry-matched controls of European ancestry, including two European-derived population isolates, Ashkenazi Jews from North America and Israel and French Canadians from Quebec, Canada. In a primary meta-analysis of GWAS data from these European ancestry samples, no markers achieved a genome-wide threshold of significance (P