학술논문
HIV infection and cardiovascular disease in women.
Document Type
article
Author
Womack, Julie; Chang, Chung-Chou; So-Armah, Kaku; Alcorn, Charles; Baker, Jason; Brown, Sheldon; Gottdiener, John; Gottlieb, Stephen; Justice, Amy; Leaf, David; McGinnis, Kathleen; Rimland, David; Rodriguez-Barradas, Maria; Sico, Jason; Skanderson, Melissa; Tindle, Hilary; Tracy, Russell; Warner, Alberta; Freiberg, Matthew; Butt, Adeel; Gibert, Cynthia; Goetz, Matthew; Budoff, Matthew
Source
Journal of the American Heart Association. 3(5)
Subject
Language
Abstract
BACKGROUND: HIV infection is associated with increased risk of cardiovascular disease (CVD) in men. Whether HIV is an independent risk factor for CVD in women has not yet been established. METHODS AND RESULTS: We analyzed data from the Veterans Aging Cohort Study on 2187 women (32% HIV infected [HIV(+)]) who were free of CVD at baseline. Participants were followed from their first clinical encounter on or after April 01, 2003 until a CVD event, death, or the last follow-up date (December 31, 2009). The primary outcome was CVD (acute myocardial infarction [AMI], unstable angina, ischemic stroke, and heart failure). CVD events were defined using clinical data, International Classification of Diseases, Ninth Revision, Clinical Modification codes, and/or death certificate data. We used Cox proportional hazards models to assess the association between HIV and incident CVD, adjusting for age, race/ethnicity, lipids, smoking, blood pressure, diabetes, renal disease, obesity, hepatitis C, and substance use/abuse. Median follow-up time was 6.0 years. Mean age at baseline of HIV(+) and HIV uninfected (HIV(-)) women was 44.0 versus 43.2 years (P