학술논문
Comparison of Kaposi Sarcoma Risk in Human Immunodeficiency Virus-Positive Adults Across 5 Continents: A Multiregional Multicohort Study
Document Type
article
Author
Judd, Ali; Zangerle, Robert; Touloumi, Giota; Warszawski, Josiane; Meyer, Laurence; Dabis, François; Krause, Murielle Mary; Ghosn, Jade; Leport, Catherine; Wittkop, Linda; Reiss, Peter; Wit, Ferdinand; Prins, Maria; Bucher, Heiner; Gibb, Diana; Fätkenheuer, Gerd; Julia, Del Amo; Obel, Niels; Thorne, Claire; Mocroft, Amanda; Kirk, Ole; Stephan, Christoph; Pérez-Hoyos, Santiago; Hamouda, Osamah; Bartmeyer, Barbara; Chkhartishvili, Nikoloz; Noguera-Julian, Antoni; Antinori, Andrea; Monforte, Antonella d’Arminio; Brockmeyer, Norbert; Prieto, Luis; Conejo, Pablo Rojo; Soriano-Arandes, Antoni; Battegay, Manuel; Kouyos, Roger; Mussini, Cristina; Tookey, Pat; Casabona, Jordi; Miró, Jose M; Castagna, Antonella; Konopnick, Deborah; Goetghebuer, Tessa; Sönnerborg, Anders; Quiros-Roldan, Eugenia; Sabin, Caroline; Teira, Ramon; Garrido, Myriam; Haerry, David; de Wit, Stéphane; Costagliola, Dominique; d’Arminio-Monforte, Antonella; del Amo, Julia; Raben, Dorthe; Chêne, Geneviève; Rojo, Conejo Pablo; Barger, Diana; Schwimmer, Christine; Termote, Monique; Campbell, Maria; Frederiksen, Casper M; Friis-Møller, Nina; Kjaer, Jesper; Brandt, Rikke Salbøl; Berenguer, Juan; Bohlius, Julia; Bouteloup, Vincent; Cozzi-Lepri, Alessandro; Davies, Mary-Anne; Dorrucci, Maria; Dunn, David; Egger, Matthias; Furrer, Hansjakob; Grabar, Sophie; Guiguet, Marguerite; Lambotte, Olivier; Leroy, Valériane; Lodi, Sara; Matheron, Sophie; Miro, Jose M; Monge, Susana; Nakagawa, Fumiyo; Paredes, Roger; Phillips, Andrew; Puoti, Massimo; Rohner, Eliane; Schomaker, Michael
Source
Clinical Infectious Diseases. 65(8)
Subject
Language
Abstract
BackgroundWe compared Kaposi sarcoma (KS) risk in adults who started antiretroviral therapy (ART) across the Asia-Pacific, South Africa, Europe, Latin, and North America.MethodsWe included cohort data of human immunodeficiency virus (HIV)-positive adults who started ART after 1995 within the framework of 2 large collaborations of observational HIV cohorts. We present incidence rates and adjusted hazard ratios (aHRs).ResultsWe included 208140 patients from 57 countries. Over a period of 1066572 person-years, 2046 KS cases were diagnosed. KS incidence rates per 100000 person-years were 52 in the Asia-Pacific and ranged between 180 and 280 in the other regions. KS risk was 5 times higher in South African women (aHR, 4.56; 95% confidence intervals [CI], 2.73-7.62) than in their European counterparts, and 2 times higher in South African men (2.21; 1.34-3.63). In Europe, Latin, and North America KS risk was 6 times higher in men who have sex with men (aHR, 5.95; 95% CI, 5.09-6.96) than in women. Comparing patients with current CD4 cell counts ≥700 cells/µL with those whose counts were