학술논문
Analysis of Using the Total White Blood Cell Count to Define Severe New-onset Ulcerative Colitis in Children.
Document Type
article
Author
Mack, David R; Saul, Bradley; Boyle, Brendan; Griffiths, Anne; Sauer, Cary; Markowitz, James; LeLeiko, Neal; Keljo, David; Rosh, Joel R; Baker, Susan S; Steiner, Steve; Heyman, Melvin B; Patel, Ashish S; Baldassano, Robert; Noe, Joshua; Rufo, Paul; Kugathasan, Subra; Walters, Thomas; Marquis, Alison; Thomas, Sonia M; Denson, Lee; Hyams, Jeffrey
Source
Journal of Pediatric Gastroenterology and Nutrition. 71(3)
Subject
Language
Abstract
ObjectivesThe aim of this study was to assess common laboratory tests in identifying severe ulcerative colitis in children at diagnosis.MethodsA cohort of 427 children 4 to 17 years of age newly diagnosed with ulcerative colitis (UC) was prospectively enrolled. Boosted classification trees were used to characterize predictive ability of disease attributes based on clinical disease severity using Pediatric Ulcerative Colitis Activity Index (PUCAI), severe (65+) versus not severe (