학술논문

Bone Mineral Density Measurements and Association With Brain Structure and Cognitive Function
Document Type
article
Source
Alzheimer Disease & Associated Disorders. 35(4)
Subject
Biological Psychology
Biomedical and Clinical Sciences
Psychology
Dementia
Osteoporosis
Alzheimer's Disease
Biomedical Imaging
Neurosciences
Brain Disorders
Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD)
Neurodegenerative
Acquired Cognitive Impairment
Clinical Research
Estrogen
Aging
Neurological
Aged
Bone Density
Brain
Cognition
Cohort Studies
Female
Femur
Humans
Male
bone mineral density
MRI
cognitive function
executive function
visual memory
verbal memory
Clinical Sciences
Cognitive Sciences
Geriatrics
Clinical sciences
Biological psychology
Language
Abstract
BackgroundBone mineral density (BMD) is a potential surrogate marker of lifetime estrogen exposure previously linked to increased risk of Alzheimer dementia among elderly women. We examine the association between BMD in the "young old" with imaging biomarkers of brain aging and cognitive performance.MethodsOffspring participants (N=1905, mean age 66) of a population-based cohort who had BMD, brain imaging and detailed cognitive assessment were included in the study. Sex-stratified, linear, and logistic regression models were used for analysis.ResultsHigher femoral neck BMD was associated with lower white matter hyperintensity burden and better performance on Trails B-A in both sexes, even after adjustment for cerebrovascular risk factors. Among women, the positive association with Trails B-A performance was seen only in APOE4 allele carriers. Higher BMD measurements were linked to better visual reproductions test performance in men. Finally, among women, higher femoral trochanter BMD was associated with better logical memory and Hooper visual organization test performance.ConclusionAmong the "young old," higher BMD is associated with less white matter hyperintensity burden and better, domain-specific, cognitive performance. This suggests that lifetime estrogen exposure may modulate the degree of cumulative vascular brain injury independent of cerebrovascular risk factors.