학술논문
Multi-tissue epigenetic analysis identifies distinct associations underlying insulin resistance and Alzheimer’s disease at CPT1A locus
Document Type
article
Author
Sarnowski, Chloé; Huan, Tianxiao; Ma, Yiyi; Joehanes, Roby; Beiser, Alexa; DeCarli, Charles S; Heard-Costa, Nancy L; Levy, Daniel; Lin, Honghuang; Liu, Ching-Ti; Liu, Chunyu; Meigs, James B; Satizabal, Claudia L; Florez, Jose C; Hivert, Marie-France; Dupuis, Josée; De Jager, Philip L; Bennett, David A; Seshadri, Sudha; Morrison, Alanna C
Source
Clinical Epigenetics. 15(1)
Subject
Language
Abstract
BackgroundInsulin resistance (IR) is a major risk factor for Alzheimer's disease (AD) dementia. The mechanisms by which IR predisposes to AD are not well-understood. Epigenetic studies may help identify molecular signatures of IR associated with AD, thus improving our understanding of the biological and regulatory mechanisms linking IR and AD.MethodsWe conducted an epigenome-wide association study of IR, quantified using the homeostatic model assessment of IR (HOMA-IR) and adjusted for body mass index, in 3,167 participants from the Framingham Heart Study (FHS) without type 2 diabetes at the time of blood draw used for methylation measurement. We identified DNA methylation markers associated with IR at the genome-wide level accounting for multiple testing (P