학술논문
Neutralizing immunity in vaccine breakthrough infections from the SARS-CoV-2 Omicron and Delta variants
Document Type
article
Author
Servellita, Venice; Syed, Abdullah M; Morris, Mary Kate; Brazer, Noah; Saldhi, Prachi; Garcia-Knight, Miguel; Sreekumar, Bharath; Khalid, Mir M; Ciling, Alison; Chen, Pei-Yi; Kumar, G Renuka; Gliwa, Amelia S; Nguyen, Jenny; Sotomayor-Gonzalez, Alicia; Zhang, Yueyuan; Frias, Edwin; Prostko, John; Hackett, John; Andino, Raul; Wadford, Debra A; Hanson, Carl; Doudna, Jennifer; Ott, Melanie; Chiu, Charles Y
Source
Cell. 185(9)
Subject
Language
Abstract
Virus-like particle (VLP) and live virus assays were used to investigate neutralizing immunity against Delta and Omicron SARS-CoV-2 variants in 259 samples from 128 vaccinated individuals. Following Delta breakthrough infection, titers against WT rose 57-fold and 3.1-fold compared with uninfected boosted and unboosted individuals, respectively, versus only a 5.8-fold increase and 3.1-fold decrease for Omicron breakthrough infection. Among immunocompetent, unboosted patients, Delta breakthrough infections induced 10.8-fold higher titers against WT compared with Omicron (p = 0.037). Decreased antibody responses in Omicron breakthrough infections relative to Delta were potentially related to a higher proportion of asymptomatic or mild breakthrough infections (55.0% versus 28.6%, respectively), which exhibited 12.3-fold lower titers against WT compared with moderate to severe infections (p = 0.020). Following either Delta or Omicron breakthrough infection, limited variant-specific cross-neutralizing immunity was observed. These results suggest that Omicron breakthrough infections are less immunogenic than Delta, thus providing reduced protection against reinfection or infection from future variants.